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Randomization and blinding

YX Yan Xing
NL Nan Lin
RH Ruquan Han
JB John F. Bebawy
YP Yuming Peng
JL Jiaxin Li
XL Xiaoyuan Liu
YL Yan Li
JD Jia Dong
MZ Min Zeng
MZ Manyu Zhang
LN Lanyi Nie
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Permuted-block randomization will be used with a block size of 4 and an allocation ratio of 1:1 to either sevoflurane-remifentanil group or propofol-remifentanil group. Random allocation sequence will be based on a computer-generated random digits table. One investigator who will not participate in anesthetic management or follow-up will implement the randomization and enroll patients, and allocation will be concealed in a sealed opaque envelope until patient enters the operating room. Randomization will occur for patients conforming to the above criteria, and written informed consent will then be obtained from themselves or their next-of-kin. Since the two general anesthetic administration routes are distinct (inhalational versus intravenous), patients and anesthesiologists cannot be blinded. An independent team who is not involved in the intraoperative management will be in charge of postoperative follow-up and is blinded to the intervention.

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