Outcome Measures

KK Khadija Khalifa
AB Anne Katrine Bergland
HS Hogne Soennesyn
KO Ketil Oppedal
RO Ragnhild Oesterhus
ID Ingvild Dalen
AL Alf Inge Larsen
TF Tormod Fladby
HB Helen Brooker
KW Keith A. Wesnes
CB Clive Ballard
DA Dag Aarsland
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Cognitive assessment: CogTrack® is an online cognitive test battery consisting of 10 subtests, which, based on factor analysis, are combined into the following domains: attention, memory, and cognitive speed. There are 14 different word lists, each with 15 words, for the verbal memory test. The instructions are presented visually at the start of each testing session and also at the start of each task. In-task responses are made using the right arrow on the keyboard in two tasks and the left and right arrows in the other two. The participants are instructed to rest their finger(s) lightly upon the key(s) throughout each task. The speed and accuracy of every response are recorded. The primary outcome measure will be the quality of episodic memory combination of two accuracy scores from each of immediate and delayed word recall, word and picture recognition (four tasks in total), which has been shown to represent the overall quality of episodic memory and to be sensitive to cognitive changes, with negligible learning effects (39, 40). The battery is completed online monthly at home, using different word-lists at each occasion.

See test detail outlines in (39).

Secondary endpoints from the CogTrack System will include:

attentional intensity index

sustained attention index

cognitive reaction time

attentional fluctuation index

quality of working memory

speed of memory retrieval.

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