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Pharmacodynamics assumptions

MW Martin Walker
JH Jonathan I. D. Hamley
PM Philip Milton
FM Frédéric Monnot
BP Belén Pedrique
MB Maria-Gloria Basáñez
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The hypothetical macrofilaricides were assumed to be either purely macrofilaricidal, with no effect on mf, or macrofilaricidal and microfilaricidal. These are referred to, respectively, as macrofilaricidal-only macrofilaricides (MOMs) or macrofilaricidal and microfilaricidal macrofilaricides (MAMMs). Macrofilaricides were assumed to kill a fraction of adult worms over three months that was varied between 60% and 90% (Table 1). The MAMMs were assumed to have microfilaricidal effects identical to the microfilaricidal dynamics (but excluding the temporary sterilising or embryostatic effect) of ivermectin, i.e., rapid depletion of mf by 98–99% after 1–2 months7.

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