We systematically searched several databases including PubMed, Embase, Web of Science, EBSCO, and the Cochrane library from January 1980 to October 2019 using the following keywords: tranexamic acid, hemostatic, blood loss, stone, and percutaneous nephrolithotomy. The reference lists of retrieved studies and relevant reviews were also hand-searched and the process above was performed repeatedly to include additional eligible studies.
The inclusion criteria are presented as follows: (1) study design is an RCT; (2) intervention treatment was TXA compared with placebo (or no intervention) for patients who underwent PCNL; (3) adequate reported data for analysis were provided; and (4) all languages were included (translated into English if necessary).
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