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Human OA tissues from TMJ joints

MT Mustafa M. Tashkandi
SA Saqer F. Alsaqer
TA Thabet Alhousami
FA Faiza Ali
YW Yu-Chiao Wu
JS Jennifer Shin
PM Pushkar Mehra
LW Larry M. Wolford
LG Louis C. Gerstenfeld
MG Mary B. Goldring
MB Manish V. Bais
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Anonymized pathological waste TMJ tissues were obtained from Boston University Medical Center, Boston, MA, through IRB approval (H33300). The exclusion criteria included a history of any rheumatic disease or cancer. The samples were selected based on clinical features such as TMJ pain and joint mobility and then confirmed as TMJ-OA by pathological diagnostic findings from TMJ tissue sections at the Department of Pathology, Boston University.

These freshly isolated TMJ condylar cartilage tissues were divided into 2 parts: (1) for preparation of fixed and stained sections for histological characterization or (2) for preparation of biopsy punches (4-mm3) for nude mice implant studies, starting from the superficial layer and extending towards proteoglycan layer in order to maintain uniformity in the implant size and shape as described below.

Copyright and License information: The Author(s) ©2020
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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