MSK-IMPACT testing

The MSK-IMPACT test involves a custom NGS gene panel that is being investigated in clinical trials at MSKCC. Three versions of the MSK-IMPACT panels, which include 341 genes, 410 genes and 468 genes, respectively, were used in this study (11). Recently, the MSK-IMPACT test was authorized by the U.S. Food and Drug Administration (FDA) as an in vitro NGS test for various cancers (12). Generally, the MSK-IMPACT test requires tumor and matched blood samples and is capable of detecting somatic single nucleotide variants, insertions, deletions, copy number alterations and select structural rearrangements in genes in human genomic DNA obtained from tumor tissue (19).