UALCAN Analysis

UALCAN (http://ualcan.path.uab.edu/) is an effective online analysis and mining website for an in-depth analysis of gene expression data using TCGA levels 3 RNA-seq and clinical data from 31 cancer types (28). It allows the relative expression of genes between tumors and normal samples, as well as in different tumor subgroups based on sample type, individual tumor stage, major subclasses, and other clinical pathological features. We entered the target gene SIRT7 on the home page of the website, selected breast invasive carcinoma, and obtained differential expression of the target gene in breast cancer tissues and normal tissues. This study will analyze the differential expression of SIRT7 from various angles such as sample type (normal/primary tumor), breast cancer subclass (luminal, HER2⁺, and triple-negative), cancer stage (stages 1, 2, 3, and 4), and menopause status (premenopause, perimenopause, and postmenopause).