C57BL/6J female mice at 8 weeks old were fed either NFD or sHFD for 3 weeks. Then, 2.5% dextran sulfate sodium (DSS) (MP Biomedicals, Santa Ana, CA) dissolved in sterile distilled drinking water was orally administered for 5 days. Then, 2.5% DSS was switched to regular drinking water for the next 3 days. The body weight and colon length of each mouse were measured.
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