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2.3. Experimental Design

WJ Wölfle-Roos JV
KB Katmer Amet B
FJ Fiedler J
MH Michels H
KG Kappelt G
IA Ignatius A
DL Dürselen L
RH Reichel H
BR Brenner RE
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The animals were randomly assigned 22 animals each to one of the following groups: (1) control group, (2) CAST 1st GEN, (3) CAST 2nd GEN, (4) CAST + CA, or (5) CAST + P group. According to which group they belonged to, one of the following implants was inserted:

Standard Ti6Al4V implants;

Cast Ti6Al4V implants of the first generation;

Cast Ti6Al4V implants of the second generation;

Cast Ti6Al4V implants of the second generation with calcium ion implantation;

Cast Ti6Al4V implants of the second generation with phosphorus ion implantation.

Eleven animals of each group were sacrificed after 4 weeks, and the remaining animals 12 weeks after implant insertion. The right tibia was prepared for biomechanical testing and the left tibia for histomorphometric analysis.

Copyright and License information:  ©2020 by the authors.
Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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