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For the estimation of beam-on time during the treatment, all acquired conformal sum doses were virtually standardized to 13 Gy by adjusting the dwell position doses in relation to each other. Here, 13 Gy represents a single-fraction dose for interstitial brachytherapy, corresponding to an equivalent dose in 2 Gy fractions (EQD2 = n × D × ((d + α/β)/(2 + α/β))) between 32.5 and 54 Gy (for an α/β-ratio between 3 and 10), considering the increased relative biological effectiveness (RBE) of 1.3 for low-energy kV-photons [2,22,23,24].
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