Patients were followed in valvular heart disease clinic in Kaplan Medical Center on 6-months clinic visit basis. The decision to preform aortic valve replacement (AVR) was done by the cardiologist based on patients' symptoms, echocardiographic data and patients’ risk, according to clinical guidelines.
The primary endpoint was all-cause and cardiac mortality. Causes of death were determined by examination of hospital records and medical files of patients' general practitioners. Deaths due to cardiovascular causes included sudden deaths and deaths from acute myocardial infarction (MI), cerebrovascular accident (CVA) or congestive heart failure (CHF).
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