Protein–protein interaction (PPI) network, which identifies key elements in RPL based on interaction level, was acquired from STRING (Search Tool for Retrieval of Interacting Genes) database. DEG were mapped to STRING to evaluate PPI information, and visualized with Cytoscape. In addition, clusters of network highly intra-connected nodes were searched by MCODE (Molecular Complex Detection) Cytoscape network plug-in (Additional file 1: Table S1) [32].
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