2.2. Drugs and chemicals

Cisplatin vials (50 mg/50 ml) were purchased from Mylan (Rockford, USA). Amlodipine was obtained as a gift from Global Napi Pharmaceuticals (6^th of October, Giza, Egypt). The chemicals used for estimation of oxidative stress biomarkers including, thiobarbituric acid, Ellman's reagent, vanadium trichloride, and sulfanilamide were purchased from Sigma-Aldrich (USA), while N-(1-naphthyl) ethylenediamine dihydrochloride was purchased from Park Scientific Ltd (UK). The suspending agent carboxymethyl cellulose (CMC) was obtained from Loba Chemie (India).