Study population

This was a retrospective Health Insurance Portability and Accountability Act–compliant study conducted at Memorial Sloan Kettering Cancer Center. The study was approved by the Institutional Review Board (protocol number 19-119) and the need for written informed consent was waived.

A review of the Department of Radiology database was performed to identify consecutive patients with genetic testing results available and who had an MRI from November 2013 to February 2019 that led to a biopsy or a short-term follow-up. We identified 430 patients. Our inclusion criteria were as follows: BRCA 1– or BRCA 2–positive patients; breast masses with the longest diameter ≤ 10 mm; and BI-RADS 3, 4, or 5 on MRI further assessed with follow-up or vacuum-assisted breast biopsy (MRI or ultrasound-guided) yielding benign or malignant histology. Findings described as non-mass enhancements on MRI were not included. We excluded patients with mutations other than BRCA 1 and 2 and those with a follow-up of less than 2 years when biopsy was not performed (BI-RADS 3 and BI-RADS 4 when target was not visualized at the time of biopsy).