Statistical analysis

Quantification of immunoblot signals was performed using the Li-COR Odyssey FC2 imaging system and Image Studio software. All experiments were repeated at least three times, unless indicated otherwise. Quantified immunoblot data were normalized between experiments as described in the figure legends and were represented as averages and SEM. The Student’s t test was used unless indicated otherwise. Significance was defined as a P value of <0.05, and the tests used for each data group are described in the figure legends. GO (gene ontology) analysis with the proteomic dataset was performed with the Panther Classification system “molecular function” annotation dataset.