For all patients, paraffin slides were used for typing and grading the tumor. Histological grading was performed according to the Scarff-Bloom-Richardson (SBR) histologic grading system, which recommends the sum of individual scores for three variables: i) Percentage of tubule differentiation; ii) degree of nuclear pleomorphism; and iii) mitotic count within a defined field area (27). From the total of samples, 28 were classified as SBR grade 8, 9 as SBR grade 6 and 22 as SBR grade 7.
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