An extensive systematic search in Embase, PubMed and Web of Science (last updated April 2020) will be conducted, using “brain-derived neurotrophic factor” and the psychiatric diagnoses “depression”, “suicide” “mania”, “unipolar depression”, “bipolar disorder”, “schizophrenia”, “attention-deficit/hyperactivity disorder”, as keywords and Medical Subject Headings. The search strategy is shown in Supplemental Digital Content (Appendix 1). It will appropriately adjust the search terms to conform to different syntax rules of the platforms and databases mentioned above.
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