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3.3. Synthesis of 4-n-Alkoxyanilines (n = 6, 8, 10, 12, 14, 16, 18, 20)

PB Pradip K. Bhowmik
MA Muhammed Kareem M. Al-Karawi
SK Shane T. Killarney
ED Erenz J. Dizon
AC Anthony Chang
JK Jongin Kim
SC Si L. Chen
RP Ronald Carlo G. Principe
AH Andy Ho
HH Haesook Han
HM Hari D. Mandal
RC Raymond G. Cortez
BG Bryan Gutierrez
KM Klarissa Mendez
LS Lewis Sharpnack
DA Deña M. Agra-Kooijman
MF Michael R. Fisch
SK Satyendra Kumar
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All the 4-n-alkoxyanilines were prepared according to the slightly modified literature procedure [41]. The modification was the use of acetone instead of N,N-dimethylformamide in the alkylation of 4-hydroxyacetanilide with the respective n-alkyl bromide followed by hydrolysis of 4-n-alkoxyacetanilide. The overall yields for the synthesis of 4-n-alkoxyamines in two-step reaction were 74%, 60%, 67%, 62%, 845, 805, 85%, and 86%.

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Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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