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Locomotor assessment

NP Nicolas Pelisch
JA Jose Rosas Almanza
KS Kyle E. Stehlik
BA Brandy V. Aperi
AK Antje Kroner
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The Basso mouse scale (BMS) open-field locomotor test (score range of 0–9) [41] was used to assess functional recovery during a period of 28 to 42 days. Mice (n = 10–15 wild-type, 9–13 CCL3−/− mice per group) were assessed for locomotor function at day 1, 3, 7, 10, and 14 post-injury and weekly thereafter by two individuals blinded to experimental conditions and trained in BMS analysis by Dr. Basso’s laboratory at Ohio State University. Consensus scores for each animal were averaged at each time point for a maximum of 9 points for the BMS score and 11 points for the subscore, which assesses finer aspects of locomotion. This locomotor assessment was performed in three separate cohorts of mice.

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