Eligibility criteria and evidence selection

The eligibility criteria for evidence selection were defined before the search. The primary inclusion criteria for research studies were as follows: (a) recruited patients with migraine and (b) treated patients with fremanezumab. Therefore, PubMed, Embase, and Web of Science were searched using terms relevant to migraine and fremanezumab in free-text, medical subject headings, and abbreviations. The search strategy was not restricted by language or date of publication.

Two authors (IHH and PCW) completed the search before February 2020 (Supplementary File ^S17) and independently identified references by screening titles and abstracts. The full texts of the selected references were then retrieved. After reviewing the full text, the authors excluded articles based on the following exclusion criteria: (a) non-RCTs; (b) studies on healthy individuals, patients without migraines, or mixed patients with general headache and migraine without a stratified analysis; (c) studies in which patients were not treated with fremanezumab or treated with combination therapy; and (d) gray literature without details. In case of disagreement between the two authors regarding evidence selection, a third experienced author (YNK) participated in the process, and a consensus was reached after discussion.