Primary outcome measures were the changes in two tasks of verbal episodic memory: (a) the RAVLT, immediate and delayed recall; and (b) the FCSRT.
The secondary outcomes included quality of life measures, subjective memory complaints and neuropsychological measures evaluating memory, language, attention and visuo-constructional functions. The choice of outcomes was based on previous literature findings and on predefined hypotheses of investigation. Inference on them was performed considering each outcome singularly (i.e., not simultaneous inference was done on all outcome, thus no multiple comparison was needed to compare outcomes results each other (see e.g., Proschan and Follmann, 1995; Bender and Lange, 2001).
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