2.1. Expression of miR-28-5p in Colon Cancer from TCGA and GEO Database

In order to determine the association between miRNAs and the colon cancer, the data of colon adenocarcinoma (COAD) was downloaded from the TCGA database (https://cancergenome.nih.gov/). We also downloaded a colon cancer dataset ({"type":"entrez-geo","attrs":{"text":"GSE49246","term_id":"49246"}}GSE49246) [15] from the GEO database. The COAD dataset from TCGA includes miRNA expression data from 453 colon cancer tissues and eight normal colon tissues. The {"type":"entrez-geo","attrs":{"text":"GSE49246","term_id":"49246"}}GSE49246 dataset includes 40 colon cancer tissues and 40 adjacent normal tissues. The expression of miR-28-5p among gastrointestinal cancers, including COAD, esophageal cancer (ESCA), liver hepatocellular carcinoma (LIHC), rectal adenocarcinoma (READ), cholangiocarcinoma (CHOL), gastric cancer (STAD), was analyzed using OncomiR website online tool (http://www.oncomir.org), which uses the data from TCGA database.