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All experimental procedures on rodents were approved by the Institutional Animal Care and Use Committee of Texas A&M University College of Dentistry. Adult Sprague-Dawley rats (weight, 125–175 g) were obtained from Charles River Laboratories (Wilmington, MA), and wild-type C57BL/6 mice were from The Jackson Laboratory (Farmington, CT). Animals were housed in a temperature (20°C ± 2°C) and humidity controlled (50%) environment on a regular light–dark schedule and given sterile food and water ad libitum.
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