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2.4. PK simulation and model analysis using Phoenix WinNonlin 8.1

FL Fangfei Liu
LF Lampson M. Fan
NM Nicholas Michael
JL Jian‐Mei Li
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PK parameters simulation was performed using the Phoenix WinNonlin 8.1 software (Certara.com). The values of plasma apocynin concentrations vs actual sampling time (1‐30 minutes) after iv injection were modeled by non‐compartmental analysis. 19 , 20 The calculated parameters included peak concentration (C max); AUC1‐30 min and AUC0‐∞ (time 0 to infinity); elimination rate constant (kel), t1/2, and plasma clearance (CL). Data collected from sampling time 1‐360 minutes after iv injection were then pooled (n = 3) and tested against various compartmental models for a best fit using Phoenix WinNonlin 8.1 software. Parameters included the Akaike's information criterion (AIC), Bayesian information criteria (BIC) and corrected AIC (AICc) calculated using the equation: AICc = AIC +2 × nParm (nParm + 1)/(nObs − nParm − 1). 21

Copyright and License information:  ©2020 The Authors. published by British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics and John Wiley & Sons Ltd
This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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