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Pharmacodynamic target

AA Alan Abdulla
OR Omar Rogouti
NH Nicole G. M. Hunfeld
HE Henrik Endeman
AD Annemieke Dijkstra
TG Teun van Gelder
AM Anouk E. Muller
BW Brenda C. M. de Winter
BK Birgit C. P. Koch
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To calculate the ƒAUC0–24/MIC and ƒCmax/MIC ratios, the clinical breakpoint of 0.5 mg/L from the EUCAST database was used [34]. This is the highest MIC from which it can be expected that ciprofloxacin under standard conditions is effective for Enterobacteriaceae, Pseudomonas spp., Acinetobacter spp., Haemophilus influenzae, Moraxella catarrhalis, and Neisseria spp. [34]. To assess the suitability of the empirical fixed dosing regimens considering ƒAUC0–24/MIC ≥ 100 and ƒCmax/MIC ≥ 8, a MIC distribution of 0.0312–8 mg/L was tested. For the targeted treatment at different MICs, the wild-type population distribution of Pseudomonas aeruginosa and the epidemiological cut-off (ECOFF) value from the EUCAST database were used [34].

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