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Definition of ischemia time

EW Erik J. Woods
AS Aubrey M. Sherry
JW John R. Woods
JH James W. Hardin
ML Michael LaFontaine
GB Gerald Brandacher
BJ Brian H. Johnstone
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Total ischemia was defined as the time interval from death (when the donor’s arterial system was cross-clamped and circulation ceased) to start of BM recovery at the processing facility. For purposes of statistical modeling, this total interval was separated into three successive and mutually exclusive time components: (a) Warm-Ischemia Time (WIT): Beginning at time of death and ending either when bones were recovered and packed on ice, or when the body was placed in a cooler. (b) Body-Cooling Time (BCT): Beginning when the body was placed in the cooler and ending when recovered bones were packed on ice. (c) Cold-Ischemia Time (CIT): Beginning when recovered bones were packed on ice and ending when processing began for extraction of HSPCs. Thus, Total Ischemia Time = (WIT) + (BCT) + (CIT). When body cooling was not used, BCT was coded zero and Total Ischemia Time = (WIT) + (CIT). Ischemia times were considered the main variables of interest in statistical models.

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