Improve Research Reproducibility A Bio-protocol resource
Concise Method
tooltip

Self-emulsification Time Determination

CJ Chen Jianxian
KS Kalsoom Saleem
MI Muhammad Ijaz
MU Masood Ur-Rehman
GM Ghulam Murtaza
MA Mulazim Hussain Asim
ask Ask a question
Favorite

The efficiency of the developed SEDDS formulations for the emulsification time was tested using a standard USP dissolution apparatus type II (Galvano Scientific, Lahore, 53700, Pakistan). Briefly, 250 µL of selected SEDDS formulations were added to 500 mL of distilled water maintained at 37 ± 0.5°C and 50 rpm. Systems were then evaluated visually according to rate of emulsification or emulsification time and appearance of final nanoemulsion. All formulations were assessed using following grading system.

Grade A: clear nanoemulsion (<1 min)

Grade B: translucent/less clear nanoemulsion (>1 min)

Grade C: slightly translucent nanoemulsion with bluish white appearance (within 2 min)

Grade D: bright milky/white emulsion (longer than 2 min)

Grade E: emulsions with either poor emulsification possessing large oil globules on the surface or no emulsion formation.20

Copyright and License information:  ©2020 Jianxian et al.
This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

Do you have any questions about this protocol?

Post your question to gather feedback from the community. We will also invite the authors of this article to respond.

post Post a Question
0 Q&A