Study design and participants

FW Fang Wang
MQ Mengyuan Qu
XZ Xuan Zhou
KZ Kai Zhao
CL Changxiang Lai
QT Qiyuan Tang
WX Wenjie Xian
RC Ruikun Chen
XL Xuan Li
ZL Zhiyu Li
QH Qing He
LL Lei Liu
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It is a retrospective, single-center case series of the 333 hospitalized patients diagnosed with COVID-19 in the third people’s hospital of Shenzhen. We recruited all the confirmed patients whose admission date was from January 10, 2020 to February 10, 2020. All 333 COVID-19 patients were classified as mild, moderate, severe or critically ill category at admission. The diagnostic standard and classifying criteria of COVID-19 were based on the interim guidance from the WHO [7].

Two cohorts were generated in our research: 323 patients with mild-moderate symptoms on admission were observed for at least 18 days to determine whether they exacerbated to severe-critically ill conditions (progressive group) or not (stable group). In addition, we analyze the other 10 patients left who were severe-critically ill from the beginning of admission separately.

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