Statistical analysis was performed with GraphPad Prism 8.2.1 using 1-way ANOVA and/or multiple linear regression (ANCOVA, for data in Figure 2D and Figure 4C) when the number of groups exceeded 2 or 2-tailed mean t test when numbers of groups equaled 2. All quantitative data are expressed as mean ± SD, and P ≤ 0.05 was considered statistically significant.
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