Kawa-COVID-19 cohort

Patients were included on a retrospective basis according to the initial contact with two national referral networks (RAISE and CEREMAIA) encompassing seven different Paris-region hospitals (Robert-Debré and Pitié-Salpétrière in Paris, Kremlin-Bicêtre, Argenteuil, Louis-Mourier, Pontoise and Créteil Hospitals). Inclusion criteria were: age under 18 years, complete or incomplete KD and positive testing for SARS-CoV-2 infection by reverse transcription PCR (RT-PCR) or serology and/or close contact with an individual confirmed with COVID-19. KD was defined by persistent fever over 5 days associated with at least four of the five following criteria: conjunctivitis, lymphadenopathy, skin rash, red and cracked lips, inflammation of hands and feet.16 Severe disease course was defined by a necessity for intensive care (at least one organ failure) and/or fatal outcome. We deliberately chose to include patients displaying clinical signs of complete or incomplete KD in order to compare them to our ‘historical’ KD cohort, prior to SARS-CoV-2 pandemic. Kawasaki shock syndrome was defined on the basis of systolic hypotension for age, a sustained decrease in systolic blood pressure from baseline of >or=20% or clinical signs of poor perfusion.17