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Mice were treated with two doses (5 × 1011 vector genomes [vg] per kg of body weight and 4 × 1012 vg/kg) of AAV8‐FIX or buffer. The groups received 500 μg abatacept (Bristol‐Myers Squibb) intraperitoneally 3 days and 1 day before injection of AAV8 vectors, and at days 1, 3, and 6 after injection. AAV8‐FIX was further injected with and without abatacept in the same way. Blood was collected from the tail at the indicated time points. Spleens were harvested on day 77.
Copyright and License information: ©2020 Zurich Switzerland. published by Wiley Periodicals, Inc. on behalf of International Society on Thrombosis and Haemostasis
This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
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