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Development of adult IV PBPK models of lisinopril

MR Memoona Rashid
MS Muhammad Sarfraz
MA Mosab Arafat
AH Amjad Hussain
NA Nasir Abbas
MS Muhammad Waqas Sadiq
MR Muhammad Fawad Rasool
NB Nadeem Irfan Bukhari
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A previously reported systematic approach [14, 35] was adopted for the development and validation of adult PBPK model of lisinopril (Fig. 1). For the development of PBPK model, all the population and drug specific parameters, including that of physicochemical and absorption, distribution metabolism and excretion (ADME), shown in Table 1 and Table 2 were entered as inputs under the respective nodes of PK-Sim.

Developmental strategy for lisinopril PBPK model

Physiological and biological input parameters for PK-Sim Simulation

47±8.3ml/min

2.82±0.0083L/h

Characteristics of the healthy population used for lisinopril PBPK model development

Copyright and License information: The Author(s) ©2020
Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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