All animal procedures in this study followed specifically the approved guidelines by the Institutional Animal Care and Use Committee of Okayama University Graduate School of Medicine (Protocol# OKU-2018807). Adult female Sprague-Dawley rats (Shimizu Laboratory Supplies Co., Ltd., Japan) weighing 200–250 g at the beginning of the study served as subjects for all experiments. Animal housing consisted of individual cages in a temperature and humidity-controlled room and maintained on a semidiurnal light-dark cycle.
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