Inclusion Criteria

Review of all slides by an expert pathologist, Dr. Neda A. Moatamed, was performed to determine inclusion in our study. Inclusion criteria for all identified samples were the following: (1) no evidence of exogenous progesterone effects in pre-therapy slides and (2) confirmation of diagnosis and response or resistance to therapy. An additional inclusion criterion was a sufficient number of FFPE slides from pre-therapy biopsies or final hysterectomy specimens to perform analyses in this study.

Thirty patients diagnosed with CAH or well-differentiated endometrial adenocarcinoma, diagnosed and treated at Olive View Medical Center in Sylmar, CA, were identified by Dr. Malaika Amneus and Dr. Mae Zakhour. Fourteen additional patients were identified at UCLA Medical Center by Dr. Neda A. Moatamed and Dr. Sanaz Memarzadeh. Twelve samples were removed from this study as they did not meet inclusion criteria outlined above. The remaining 32 samples were included in our study. Twenty patients in this cohort were classified as progesterone-sensitive and 12 were classified as having progesterone-resistant disease. Demographic and treatment information for this patient cohort is reported (Table ​(Table11).

Patient demographics