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Tau transgenic mice

FV Francesca Vitale
JO Jasmin Ortolan
BV Bruce T. Volpe
PM Philippe Marambaud
LG Luca Giliberto
Cd Cristina d’Abramo
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JNPL3 mice obtained from Taconic (Germantown, NY) express 0N4R human tau with the P301L mutation that causes frontotemporal dementia in humans, under the mouse prion promoter. JNPL3 mice develop NFTs-like pathology as early as 4.5 months and in later stages progressive deterioration of the motor function [62]. Homozygous P301S were obtained from Dr. Michel Goedert (Cambridge, UK) [63]: these mice, on pure C57BL/6 background, express 0N4R human tau carrying the P301S mutation, under the control of the neuron-specific murine Thy-1 promoter, and they develop widespread tau pathology affecting cerebral cortex, hippocampus and brain stem as early as 6 months, and partial paralysis of the lower limbs by 8 months of age. Animals were treated according to the current regulations for the proper handling of research animals, following an approved IACUC protocol.

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