Three study groups were created: group 1 (control group) received a standard contrast dose of 120 ml; group 2 (calculator group) received an injector-calculated contrast agent dose (40–150 ml), and group 3 (calculator + dilution group) received an additional dilution of 50% on top of the injector-calculated dose.
In case of a mild to moderate degree of renal impairment (creatinine 1.5–2.0 mg/dl), patients were randomly assigned to group 2 or 3, to allow contrast dose reduction in these patients. Also in the absence of any contrast agent study protocol, contrast agent dose would have been reduced in these patients, typically by 20%.
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