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The measure of efficacy of the intervention (effect size) was computed as standardized differences, using Hedge’s improved estimate of Cohen’s d [35], from the clinician-rated CGI-S score change from baseline to the final visit of each study. The CGI-S was the only variable common to all three studies included. The two RCT also evaluated symptom remission with the HDRS-17. Therefore, a secondary endpoint of this meta-analysis was the effect size calculated from HDRS-17 score change from baseline to the final visit of each study.
Copyright and License information: ©2019 by the authors.
Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
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