Ethics statement

Housing of animals and animal experimentations were conducted under animal care procedures in strict accordance with the guidelines set by the European Community Council Directives (2010/63/UE) as well as with the national guidelines (ID 39/2009). All mice used in this study were killed by cervical dislocation. Experimental procedures relative to Figs ​Figs1,1, ​,3,3, ​,44 and ​and66 were approved by the Institutional Animal Care and Use Committee CECCAPP, Lyon, France (# ENS-2009-027 et # ENS-2012-046). Experimental procedures relative to Fig 5 were performed under supervision of the Professional committee for guarantee of good life-conditions of experimental animals at the Institute of Experimental Medicine, the Czech Academy of Sciences, Prague, Czech Republic, and approved by the Expert Committee at the Academy of Sciences of the Czech Republic (permit number: 81/2017).