2.5. Constructing the Ingredient-Target Network of Drynariae Rhizoma

The common gene targets of DR and fracture were introduced into the Cytoscape software (Version 3.4.0) to construct an ingredient-target network of Drynariae Rhizoma and analyze the topology properties of the network, including degree, betweenness centrality, and closeness centrality [18]. The degree describes the number of connections to a node in the network, indicating interaction with other nodes in the network. Betweenness centrality measures the proportion of a node between shortest paths among other nodes, suggesting the importance of nodes in maintaining network tightness. Closeness centrality indicates the degree of nodes close to the “center” of the network. A node with high degree, betweenness centrality, and closeness centrality values means that it plays a very important role in the network [18].