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Pharmaceutical-grade monocomponent PTx vaccine was provided by MassBiologics (Mattapan, MA). The single-component PTx was produced from PT purified from fermentation cultures of B. pertussis and then inactivated with hydrogen peroxide. The PTx was adsorbed to aluminum hydroxide. The vaccine was formulated at 40 μg/mL of PTx and 1 mg/mL of Alhydrogel. The baboon dose was 0.5 ml administered intramuscularly.
Copyright and License information: ©2018 Published by Oxford University Press for the Infectious Diseases Society of America 2018.
This work is written by (a) US Government employee(s) and is in the public domain in the US.
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