Facial vein phlebotomy

Facial vein phlebotomy was performed in the respective cohorts (as specified in S1 Table) at d 0, d 5, and d 14, as described recently [27]. For this, mice were grabbed by the scruff of the neck to gently but firmly immobilize head, neck, and forelimbs without anaesthesia. The right lateral facial vein was then punctured with a 20-gauge needle. Phlebotomy was performed by the same trained and experienced person throughout the study. Approximately 15 μl of blood were collected with the Protein Saver Card (Whatman 903™, GE Healthcare Europe GmbH, Freiburg, Germany) to be stored as dried blood spots at room temperature for further analyses.