Medical records of all subjects were retrospectively reviewed. Baseline clinical information including age of onset, sex, height, weight, blood lipid levels, anti-aquaporin-4 (AQP4) status, serum glucose level, clinical symptoms, therapy regimens, and comorbidities were collected. Expanded Disability Status Scale (EDSS) at the time of the first attack was carefully evaluated by a professional neurologist and recorded as initial EDSS. Baseline EDSS before the first attack was considered to be normal in all cases.
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