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Trial design

DG Daniel Yam Thiam Goh
MM Meng Wai Mun
WL Wei Liang Jerome Lee
OT Oon Hoe Teoh
DR Dimple D. Rajgor
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This was a randomised, two-period crossover study in which the subjects were randomly assigned to one of the two sequences of the interventions (Trial Registration: ClinicalTrials.gov, NCT03252574, August 17, 2017). The study was approved by the National Healthcare Group Domain Specific Review Board (NHG DSRB Reference: 2015/01059) and the informed consent was obtained from the parent or legal guardian as well as consent/assent as appropriate from children, prior to enrolment in the study for their study participation. All methods were performed in accordance with the relevant guidelines and regulations.

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