Serum and plasma samples were collected every 60 min during 240 min histone infusion in rats. Serum creatinine levels were determined using BioMajesty JCA-BM6070 (Jeol Ltd., Tokyo, Japan). Plasma tumor necrosis factor-α levels were determined using Rat TNF-alpha ELISA Kit (Bender MedSystems GmbH, Vienna, Austria), according to the manufacturer's instruction.
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