The integrative efficacy of the ingredients in ZJW was determined by analyzing the ingredients and targets interactions obtained from TCMSP Database and STITCH DataBase [20] (http://stitch.embl.de/, ver. 4.0) with the species limited as “Homo sapiens”. STITCH was a database to explore known and predicted interactions between chemicals and proteins. Only the proteins which had direct interactions with each chemical in ZJW were selected as the putative targets.
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