RGD peptide (c(RGDyC)) was obtained from GL Biochem Ltd. (Shanghai, China). Doxorubicin was obtained from Beijing Huafeng United Technology Co. MTT, calcein-AM, propidium iodide (PI), prostaglandin E1 and Sulfo-SMCC were purchased from Sigma-Aldrich. 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) and 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(Lissamine rhodamine B sulfonyl) (DOPE-RhB, excitation/emission = 560/583 nm) were purchased from Avanti Polar Lipids. All other chemicals and reagents were of analytical grade. De-ionized water (18.2 MΩ cm) from a Milli-Q purification system was used in all preparations.
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