All the rats were randomly divided into six groups, with seven rats per group: normal control group (NCG, the normal rats given water), diabetic control group (DCG, the diabetic rats given water), Met group (MG, diabetic rats given 200 mg/kg Met hydrochloride), high-dose PSPE group (PSPE 200, the diabetic rats given 200 mg/kg PSPE), medium-dose PSPE group (PSPE 100, diabetic rats given 100 mg/kg PSPE), and low-dose PSPE group (PSPE 50, the diabetic rats given 50 mg/kg PSPE). PSPE solutions were given through daily oral gavages (at 10 ml/kg BW) for 4 weeks.
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