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The sample size was calculated based on the CCA blood flow results reported previously [11]. With an expected difference of 10 cm/s in peak systolic velocity of the CCA between group means, an SD of 10 cm/s, α = 0.05, and β = 0.8, a sample size of 17 patients was required in each group. To compensate for a dropout rate of up to 10%, we will enrol a total of 38 cases (19 for each group) for this study. Although the study is powered to allow a 15% dropout rate, we will make every effort to minimise patient loss and missing data during the trial period.
Copyright and License information: The Author(s). ©2018
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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