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Pharmacokinetic assessments

TM Toby M. Maher
JS Juliet K. Simpson
JP Joanna C. Porter
FW Frederick J. Wilson
RC Robert Chan
RE Rhena Eames
YC Yi Cui
SS Sarah Siederer
SP Simon Parry
JK Julia Kenny
RS Robert J. Slack
JS Jagdeep Sahota
LP Lyn Paul
PS Peter Saunders
PM Philip L. Molyneaux
PL Pauline T. Lukey
GR Gaia Rizzo
GS Graham E. Searle
RM Richard P. Marshall
AS Azeem Saleem
AK Arthur R. Kang’ombe
DF David Fairman
WF William A. Fahy
MV Mitra Vahdati-Bolouri
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PK blood samples (2 mL) were collected at pre-dose, and at 15 and 30 min, 1, 2, 4, 8, 12, 18 and 24 h post-dose in dosing period 1, and on Day 1 (pre-dose, 15 and 30 min, 2 and 4 h post-dose) and Day 2 (on arrival and discharge at the imaging unit) in dosing period 2. Plasma samples were analysed for GSK3008348 using a validated analytical method based on protein precipitation extraction followed by liquid chromatography tandem mass spectrometry (LC-MS/MS) (Covance, Harrogate, UK). The lower limit of quantification for GSK3008348 was 50 pg/mL using a 50-μL aliquot of human plasma with an upper limit of quantification of 50,000 pg/mL.

Copyright and License information: The Author(s) ©2020
Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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