Data are presented as the mean ± standard deviation or the number and percentage. Categorical variables were compared using the chi-squared test and continuous variables were analyzed using student’s t-test. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using the Cox proportional hazard model. All statistical tests were two-sided, conducted at a significance level of 0.05, and reported using a P-value and/or 95% CIs. Incidence pattern trends were analyzed using a Cochran-Armitage trend test. All analyses were performed using SAS software, version 9.4 (SAS Institute, Cary, NC, USA).
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